Transforming Growth Factor - j 31 and P 2 Positively Regulate TGF - / 31 mRNA Expression in Trabecular Cells
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چکیده
effect of the mutations causing resistance on the pathogenicity of adenovirus will be addressed in our animal models. The frequency and pathogenicity of anticipated cidofovir-resistant adenoviruses and herpesviruses in a clinical setting remain to be established. Of note, HSV-1 variants resistant to antiviral acyclovir, though readily isolated in culture, occasionally are reported in immunosuppressed patients with AIDS. However, such variants are exceedingly rare in immunocompetent patients. In this setting, the loss of viral thymidine kinase leads to considerable reduction in pathogenicity and neurovirulence, both in animal models and in humans.
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